1. About esomeprazole

Esomeprazole reduces the quantity of acid your abdomen makes. It is used for heartburn, acid reflux disorder and gastro-oesophageal reflux illness (GORD) – GORD is whenever you maintain getting acid reflux disorder. It is also taken to stop and deal with abdomen ulcers.

Generally, esomeprazole is taken for a uncommon sickness attributable to a tumour within the pancreas or intestine referred to as Zollinger-Ellison syndrome.

Esomeprazole additionally comes combined with naproxen, a medication that reduces irritation and ache in joints and muscular tissues. Esomeprazole comes as capsules, tablets, granules and as a liquid.

All varieties of esomeprazole can be found on prescription. You can even purchase the lowest-strength 20mg tablets and capsules from pharmacies.

2. Key info

It is typical to take esomeprazole as soon as a day within the morning. Frequent unwanted side effects embrace headache, diarrhoea and abdomen ache. These are usually delicate and go away whenever you cease taking the medication.

Esomeprazole is named by the model names Nexium, Nexium Management, Emozul and Ventra. When esomeprazole is combined with naproxen it is referred to as the by model title Vimovo.

When you’ve purchased esomeprazole with no prescription and your signs do not enhance after 2 weeks, see a health care provider earlier than taking any extra.

3. Who can and can’t take esomeprazole

Esomeprazole will be taken by adults. Youngsters ought to solely have esomeprazole if their physician prescribes it.

Esomeprazole is not appropriate for some folks. To make it possible for it’s secure for you, inform your physician in the event you:

  • have had an allergic response to esomeprazole or another medicines prior to now
  • have liver issues
  • can not soak up sure varieties of sugars together with glucose or sucrose
  • are on account of have an endoscopy
  • Ask your physician in the event you ought to cease taking esomeprazole a couple of weeks earlier than your endoscopy. It’s because esomeprazole might conceal a few of the issues that might often be noticed throughout an endoscopy.

4. How and when to take it

It is typical to take esomeprazole as soon as a day, very first thing within the morning. You possibly can take it with or with out meals.

When you take esomeprazole twice a day, take one dose within the morning and one dose within the night.

Swallow tablets entire with a drink of water. In case you have issues swallowing tablets, you may put them in a glass of water. Stir till the tablets begin to break up, then drink right away.

In case you have issues swallowing capsules, you may open up esomeprazole capsules and empty the contents right into a glass. Combine with some water and drink right away. Fill the glass with water once more, and drink that as effectively to ensure there isn’t any medication left on the backside of the glass.

In case your little one is below 12 years outdated, their physician might prescribe esomeprazole granules which are available sachets. Empty the granules right into a glass and blend with some water, then encourage them to drink it right away.

How a lot to take

Every pill or capsule comprises 20mg or 40mg. Every sachet comprises 10mg.

The standard dose to deal with:

  • heartburn and acid reflux disorder is 20mg a day
  • gastro-oesophageal reflux illness is 20mg to 40mg a day
  • abdomen ulcers is 20mg a day
  • Zollinger-Ellison syndrome is 80mg a day – this will enhance to 160mg a day relying on how effectively it really works for you
  • Doses are often decrease for kids and other people with liver issues.

Will my dose go up or down?

Generally your physician will enhance your dose if it is not working effectively sufficient.

Relying on the rationale you’re taking esomeprazole, chances are you’ll take the next dose to start with, often for a month or two. After this, your physician might suggest that you just take a decrease dose.

How lengthy will I take it for?

In case you have purchased the medication your self from a pharmacy or grocery store, inform your physician in the event you really feel no higher after taking esomeprazole for two weeks. They could need to do assessments to seek out out what’s inflicting your signs or change you to a distinct medication.

When you take it on prescription, chances are you’ll solely take it for a couple of weeks or months, relying in your sickness. Generally your physician might advise you to take it for longer, even a few years.

Your physician might recommend taking esomeprazole solely when you’ve signs. This implies you will not need to take it every single day. As soon as you are feeling higher, you may cease taking it – typically after a couple of days or even weeks. Taking esomeprazole this manner is not appropriate for everybody. Communicate to your physician about what’s finest for you.

What if I overlook to take it?

When you often take it:

as soon as a day, take the missed dose as quickly as you keep in mind, except it is lower than 12 hours till your subsequent dose – through which case skip the missed dose.

twice a day, take the missed dose as quickly as you keep in mind, except it is lower than 4 hours till your subsequent dose – through which case skip the missed dose.

Don’t take a double dose to make up for a forgotten dose. When you typically overlook doses, it could assist to set an alarm to remind you. You may additionally ask your pharmacist for recommendation on different methods to recollect your medication.

What if I take an excessive amount of?

It is rather unlikely that taking one or two additional doses by chance will trigger any issues. Nonetheless, examine together with your physician in case you have taken an excessive amount of and have any of those signs:

  • feeling sweaty
  • a quick heartbeat
  • feeling sleepy
  • blurred imaginative and prescient
  • feeling confused or agitated

5. Unintended effects

Most individuals who take esomeprazole should not have any unwanted side effects. When you do get a aspect impact, it’s often delicate and can go away whenever you cease taking esomeprazole.

Frequent unwanted side effects

Frequent unwanted side effects might occur in additional than 1 in 100 folks. Speak to your physician or pharmacist if these unwanted side effects hassle you or do not go away:

  • complications
  • diarrhoea
  • feeling or being sick (nausea or vomiting)
  • constipation
  • abdomen ache or wind

Critical unwanted side effects

Critical unwanted side effects occur in lower than 1 in 1,000 folks. Name a health care provider right away in case you have:

joint ache and irregular adjustments in your pores and skin, particularly in components of your physique uncovered to the solar, resembling a crimson, raised rash in your arms that may unfold, blisters, or a crimson rash in your cheeks and nostril. These will be indicators of a uncommon situation referred to as subacute cutaneous lupus erythematosus. This will occur even in the event you’ve been taking esomeprazole for a very long time.

yellow pores and skin, darkish pee and tiredness. These will be indicators of liver issues.

Critical allergic response

In uncommon circumstances, it is doable to have a severe allergic response (anaphylaxis) to esomeprazole.

Rapid motion required:

you get a pores and skin rash which will embrace itchy, crimson, swollen, blistered or peeling pores and skin

  • you are wheezing
  • you get tightness within the chest or throat
  • you’ve bother respiratory or speaking
  • your mouth, face, lips, tongue or throat begin swelling

You may be having a severe allergic response and may have quick remedy in hospital.

These should not all of the unwanted side effects of esomeprazole. For a full record see the leaflet inside your medicines packet.

Info:

You possibly can report any suspected aspect impact utilizing the Yellow Card security scheme.

Go to Yellow Card for additional data.

6. How to deal with unwanted side effects

What to do about:

complications – ensure you relaxation and drink loads of fluids. Don’t drink an excessive amount of alcohol. Ask your pharmacist to suggest a painkiller.

diarrhoea – drink loads of water to keep away from dehydration. Indicators of dehydration embrace peeing lower than typical or having strong-smelling pee.

feeling or being sick (nausea or vomiting) – strive taking esomeprazole with or after a meal or snack. It might additionally assist in the event you do not eat wealthy or spicy meals whilst you’re taking this medication.

constipation – eat extra high-fibre meals resembling recent fruit and greens and cereals, and drink loads of water. Attempt to train recurrently, for instance, by going for a day by day stroll or run. If this does not assist, speak to your pharmacist or physician.

abdomen ache or wind – avoid meals that trigger wind like lentils, beans and onions. It may also assist to eat smaller and extra frequent meals, eat and drink slowly, and train recurrently. Some pharmacy treatments, resembling simethicone might relieve signs of wind.

7. Being pregnant and breastfeeding

  • Esomeprazole is not often advisable throughout being pregnant as there isn’t any agency proof it is secure.
  • A medication referred to as omeprazole, which has similarities to esomeprazole, is secure in being pregnant.
  • Nonetheless, in the event you’re pregnant, it is at all times higher to attempt to deal with your signs with out taking a medication.
  • Your physician or midwife might recommend consuming smaller meals extra typically and avoiding fatty and spicy meals.
  • They could additionally recommend elevating the top of your mattress 10 to 20cm by placing one thing below your mattress or mattress, in order that your chest and head are above your waist. This helps cease abdomen acid travelling up in the direction of your throat.
  • If these life-style adjustments do not work, chances are you’ll be advisable omeprazole to assist ease your signs.

Esomeprazole and breastfeeding

Esomeprazole might get into breast milk, nevertheless it’s not identified whether or not it harms the newborn. A medication referred to as omeprazole, which has similarities to esomeprazole, is secure to take whereas breastfeeding. Communicate to your physician to debate what’s finest for you and your child.

Non-urgent recommendation: Inform your physician in the event you’re:

  • attempting to get pregnant
  • pregnant
  • breastfeeding

8. Cautions with different medicines

Some medicines can intrude with esomeprazole and make you extra more likely to have unwanted side effects.

Inform your physician in the event you’re taking these medicines earlier than you begin taking esomeprazole:

  • digoxin (a coronary heart medication)
  • cilostazol (a medication used to deal with painful legs attributable to poor circulation)
  • antifungal medicines resembling itraconazole, ketoconazole or posaconazole
  • methotrexate (a medication used to deal with most cancers and situations like psoriasis and rheumatoid arthritis)
  • HIV medicines
  • phenytoin (an anti-epilepsy medication)
  • rifampicin (an antibiotic)
  • blood thinning medicines, resembling clopidogrel
  • citalopram, escitalopram, clomipramine or imipramine (antidepressants)
  • tacrolimus (a medication used for eczema or to stop organ rejection after a transplant)
  • These should not all of the medicines that won’t combine effectively with esomeprazole. For a full record see the leaflet inside your medicines packet.

Mixing esomeprazole with natural treatments and dietary supplements

Don’t take St John’s wort, the natural treatment for despair, whilst you’re taking esomeprazole. St John’s wort might cease esomeprazole working in addition to it ought to.

Necessary: Medication security

Inform your physician or pharmacist in the event you’re taking another medicines, together with natural medicines, nutritional vitamins or dietary supplements.

9. Frequent questions

  1. How does esomeprazole work?

    Esomeprazole is a sort of medication referred to as a proton pump inhibitor (PPI). Proton pumps are tiny substances within the lining of the abdomen which assist it make acid to digest meals.

    Esomeprazole prevents proton pumps from working correctly. This reduces the quantity of acid the abdomen makes.

  2. When will I really feel higher?

    You need to begin to really feel higher inside 2 to three days. It might take as much as 4 weeks for esomeprazole to work correctly so you should still have some acid signs throughout this time.

    When you purchased esomeprazole with no prescription, and really feel no higher after 2 weeks, inform your physician. They could need to do assessments or change you to a distinct medication.

  3. Is it secure to take esomeprazole for a very long time?

    When you take esomeprazole for greater than 3 months, the degrees of magnesium in your blood might fall. This will make you are feeling drained, confused, dizzy and trigger muscle twitches, shakiness and an irregular heartbeat. When you get any of those signs, inform your physician.

    Taking esomeprazole for greater than a 12 months might enhance your probabilities of sure unwanted side effects, together with: bone fractures intestine infections vitamin B12 deficiency – signs embrace feeling very drained, a sore and crimson tongue, mouth ulcers and pins and needles.

    When you take esomeprazole for longer than 1 12 months, your physician will recurrently examine your well being to see in the event you ought to stick with it taking it. It is not identified if esomeprazole works much less effectively the longer you're taking it. When you really feel prefer it is not working any extra, speak to your physician.

  4. Does taking esomeprazole for a very long time trigger abdomen most cancers?

    A Hong Kong research revealed in 2017 instructed that folks taking proton pump inhibitors (PPIs) like esomeprazole for a minimum of 3 years have a really small elevated probability of creating abdomen most cancers. For each 10,000 folks taking a PPI long run, it was thought an additional 4 folks get abdomen most cancers.

    Nonetheless, the research did not show that PPIs have been inflicting abdomen most cancers and the outcomes might not apply within the UK.

    Individuals who take PPIs recurrently should not be significantly involved by this research. Nonetheless, like most medicines, PPIs have unwanted side effects, so it is best to take them for the shortest time doable. Communicate to your physician or pharmacist in case you are involved.

  5. How do I come off esomeprazole?

    Normally, you may cease taking esomeprazole with out decreasing the dose first. When you've taken esomeprazole for a very long time communicate to your physician earlier than you cease taking it.

    Stopping abruptly may make your abdomen produce much more acid, and make your signs come again. Lowering the dose steadily earlier than stopping utterly will stop this taking place.

  6. Are there comparable medicines?

    There are 4 different medicines which are much like esomeprazole. They're:

    -lansoprazole
    -omeprazole
    -pantoprazole
    -rabeprazole

    Like esomeprazole, these medicines are proton pump inhibitors. They work in the identical means as esomeprazole to cut back acid in your abdomen. They typically work in addition to esomeprazole and have comparable unwanted side effects, however could also be given in numerous doses.

    Generally, if esomeprazole is not working or would not agree with you, your physician might recommend that you just strive taking one other proton pump inhibitor.

  7. Are there different indigestion medicines?

    There are different pharmacy and prescription medicines for indigestion and heartburn. Antacids, like calcium carbonate (Tums), sodium bicarbonate, Maalox and Milk of Magnesia, relieve indigestion and heartburn by neutralising the acid in your abdomen. They provide fast aid that lasts for a couple of hours. They're excellent for infrequent abdomen acid signs.

    Some antacids, resembling Gaviscon, have an additional ingredient referred to as alginic acid. They work by lining your abdomen in order that juices from it do not splash up into your food pipe.

    They're particularly good for relieving acid reflux disorder. Antacids can be found from pharmacies and supermarkets. H2 blockers (histamine antagonists) cut back the quantity of acid made in your abdomen, however they do that otherwise to proton pump inhibitors. They embrace famotidine (Pepcid), ranitidine (Zantac), cimetidine (Tagamet) and nizatidine (Axid).

    On the whole, proton pump inhibitors like esomeprazole are used first as a result of they're higher than H2 blockers at decreasing abdomen acid. Nonetheless, if you aren't getting on with a proton pump inhibitor (for instance, due to unwanted side effects), your physician might prescribe an H2 blocker.

    You should buy famotidine and ranitidine with no prescription from pharmacies.

  8. Can I take esomeprazole with an antacid?

    You possibly can take esomeprazole with an antacid, for instance Gaviscon. Take it 2 hours earlier than or after your dose of esomeprazole.

  9. Can I take painkillers with it?

    Sure, it is secure to take painkillers resembling paracetamol or ibuprofen concurrently esomeprazole. It is best to take ibuprofen with, or simply after, a meal so it would not upset your abdomen.

  10. Will it have an effect on my fertility?

    There is not any agency proof to recommend that taking esomeprazole will cut back fertility in both males or girls.

    Nonetheless, communicate to a pharmacist or your physician in the event you're attempting to get pregnant. They could need to evaluate your remedy.

  11. Will it have an effect on my contraception?

    Esomeprazole would not have an effect on any kind of standard contraception together with the mixed capsule. It might cut back the effectiveness of 1 kind of emergency contraception referred to as ellaOne (ulipristal), so a distinct emergency contraceptive could also be advisable as a substitute.

  12. Can I drive or journey a motorbike?

    Sometimes, esomeprazole could make you are feeling dizzy or sleepy or have an effect on your imaginative and prescient. If this occurs to you, don't drive, cycle or use equipment or instruments till you are feeling higher.

  13. Alkohola edan al dezaket horrekin?

    Sure, you may drink alcohol with esomeprazole. Nonetheless, ingesting alcohol makes your abdomen produce extra acid than regular. This will irritate your abdomen lining and make your signs worse.

  14. Is there any meals or drink I must keep away from?

    You possibly can eat and drink usually whereas taking esomeprazole. Nonetheless, you must keep away from meals that appear to make your indigestion worse, resembling wealthy, spicy and fatty meals. You also needs to minimize down on caffeinated drinks, resembling tea, espresso and cola, in addition to alcohol.

  15. Can life-style adjustments assist?

    It might be doable to ease signs attributable to an excessive amount of abdomen acid by making a couple of adjustments to your food regimen and life-style: keep a wholesome weight by consuming healthily don't eat meals that may make your signs worse, resembling wealthy, spicy and fatty meals, and acidic meals like tomatoes, citrus fruits, salad dressings and fizzy drinks Minimize down on caffeinated drinks, resembling tea, espresso and cola, in addition to alcohol and smoking in case you have signs at evening, strive to not eat for a minimum of 3 hours earlier than you go to mattress increase the top of your mattress 10 to 20cm by placing one thing below your mattress or mattress in order that your chest and head are above your waist.

Associated situations

  • Heartburn and acid reflux disorder
  • Indigestion
  • Abdomen ulcer
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